3g5c

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{{STRUCTURE_3g5c| PDB=3g5c | SCENE= }}
 
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===Structural and biochemical studies on the ectodomain of human ADAM22===
 
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{{ABSTRACT_PUBMED_019692335}}
 
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==About this Structure==
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==Structural and biochemical studies on the ectodomain of human ADAM22==
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[[3g5c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5C OCA].
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<StructureSection load='3g5c' size='340' side='right'caption='[[3g5c]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5c OCA], [https://pdbe.org/3g5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5c RCSB], [https://www.ebi.ac.uk/pdbsum/3g5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADA22_HUMAN ADA22_HUMAN] Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.<ref>PMID:12589811</ref> <ref>PMID:15882968</ref> <ref>PMID:16385342</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5c ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[A Disintegrin And Metalloproteinase|A Disintegrin And Metalloproteinase]]
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*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
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*[[Molecular Playground/ADAM13|Molecular Playground/ADAM13]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019692335</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, X.]]
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[[Category: Large Structures]]
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[[Category: He, X.]]
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[[Category: Chen X]]
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[[Category: Liu, H.]]
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[[Category: He X]]
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[[Category: Shim, A.]]
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[[Category: Liu H]]
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[[Category: Alpha/beta fold]]
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[[Category: Shim A]]
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[[Category: Cell adhesion]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Cross-linked domain]]
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[[Category: Egf-like domain]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Phosphoprotein]]
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[[Category: Transmembrane]]
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Current revision

Structural and biochemical studies on the ectodomain of human ADAM22

PDB ID 3g5c

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