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1bxw

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{{STRUCTURE_1bxw| PDB=1bxw | SCENE= }}
 
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===OUTER MEMBRANE PROTEIN A (OMPA) TRANSMEMBRANE DOMAIN===
 
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{{ABSTRACT_PUBMED_9808047}}
 
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==About this Structure==
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==OUTER MEMBRANE PROTEIN A (OMPA) TRANSMEMBRANE DOMAIN==
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[[1bxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_bl21(de3) Escherichia coli bl21(de3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXW OCA].
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<StructureSection load='1bxw' size='340' side='right'caption='[[1bxw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BXW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxw OCA], [https://pdbe.org/1bxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bxw RCSB], [https://www.ebi.ac.uk/pdbsum/1bxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bxw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OMPA_ECOLI OMPA_ECOLI] Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/1bxw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bxw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The outer membrane protein A of Escherichia coli (OmpA) is an intensely studied example in the field of membrane protein folding. We have determined the structure of the OmpA transmembrane domain consisting of residues 1-171, by X-ray diffraction analysis, to a resolution of 2.5 A. It consists of a regular, extended eight-stranded beta-barrel and appears to be constructed like an inverse micelle with large water-filled cavities, but does not form a pore. Surprisingly, the cavities seem to be highly conserved during evolution. The structure corroborates the concept that all outer membrane proteins consist of beta-barrels. The structure constitutes a beta-barrel membrane anchor that appears to be the outer membrane equivalent of the single-chain alpha-helix anchor of the inner membrane.
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==See Also==
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Structure of the outer membrane protein A transmembrane domain.,Pautsch A, Schulz GE Nat Struct Biol. 1998 Nov;5(11):1013-7. PMID:9808047<ref>PMID:9808047</ref>
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*[[Homology modeling servers|Homology modeling servers]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:009808047</ref><references group="xtra"/>
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</div>
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[[Category: Pautsch, A.]]
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<div class="pdbe-citations 1bxw" style="background-color:#fffaf0;"></div>
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[[Category: Schulz, G E.]]
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[[Category: Membrane protein]]
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==See Also==
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[[Category: Outer membrane]]
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*[[Porin 3D structures|Porin 3D structures]]
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[[Category: Transmembrane protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pautsch A]]
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[[Category: Schulz GE]]

Current revision

OUTER MEMBRANE PROTEIN A (OMPA) TRANSMEMBRANE DOMAIN

PDB ID 1bxw

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