1aoi

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{{STRUCTURE_1aoi| PDB=1aoi | SCENE= }}
 
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===COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT===
 
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{{ABSTRACT_PUBMED_9305837}}
 
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==About this Structure==
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==COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT==
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[[1aoi]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The July 2000 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nucleosome'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2000_7 10.2210/rcsb_pdb/mom_2000_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOI OCA].
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<StructureSection load='1aoi' size='340' side='right'caption='[[1aoi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1aoi]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The July 2000 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nucleosome'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2000_7 10.2210/rcsb_pdb/mom_2000_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AOI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aoi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoi OCA], [https://pdbe.org/1aoi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aoi RCSB], [https://www.ebi.ac.uk/pdbsum/1aoi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aoi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ao/1aoi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aoi ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Histone|Histone]]
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*[[Histone 3D structures|Histone 3D structures]]
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*[[Nucleosomes|Nucleosomes]]
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__TOC__
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*[[User:Eric Martz/Nucleosomes|User:Eric Martz/Nucleosomes]]
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</StructureSection>
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*[[User:Luca Toldo|User:Luca Toldo]]
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:009305837</ref><ref group="xtra">PMID:018160966</ref><references group="xtra"/>
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[[Category: Nucleosome]]
[[Category: Nucleosome]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Luger, K.]]
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[[Category: Luger K]]
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[[Category: Maeder, A W.]]
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[[Category: Maeder AW]]
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[[Category: Richmond, R K.]]
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[[Category: Richmond RK]]
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[[Category: Richmond, T J.]]
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[[Category: Richmond TJ]]
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[[Category: Sargent, D F.]]
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[[Category: Sargent DF]]
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[[Category: Chromatin]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Histone]]
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[[Category: Nucleoprotein]]
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[[Category: Nucleosome]]
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[[Category: Protein dna interaction]]
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[[Category: Supercoiled dna]]
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Current revision

COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT

PDB ID 1aoi

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