1l2q

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{{STRUCTURE_1l2q| PDB=1l2q | SCENE= }}
 
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===Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)===
 
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{{ABSTRACT_PUBMED_12029132}}
 
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==About this Structure==
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==Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)==
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[[1l2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA].
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<StructureSection load='1l2q' size='340' side='right'caption='[[1l2q]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=XPL:N~6~-[(3R,5R)-5-AMINO-3-METHYL-D-PROLYL]-L-LYSINE'>XPL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2q OCA], [https://pdbe.org/1l2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2q RCSB], [https://www.ebi.ac.uk/pdbsum/1l2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTMB1_METBA MTMB1_METBA] Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).<ref>PMID:9642198</ref> <ref>PMID:9195968</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.
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==See Also==
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A new UAG-encoded residue in the structure of a methanogen methyltransferase.,Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK Science. 2002 May 24;296(5572):1462-6. PMID:12029132<ref>PMID:12029132</ref>
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*[[Pyrrolysine|Pyrrolysine]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:012029132</ref><references group="xtra"/>
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</div>
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<div class="pdbe-citations 1l2q" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monomethylamine methyltransferase|Monomethylamine methyltransferase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]
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[[Category: Chan, M K.]]
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[[Category: Chan MK]]
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[[Category: Ferguson, T K.]]
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[[Category: Ferguson TK]]
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[[Category: Gong, W.]]
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[[Category: Gong W]]
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[[Category: Hao, B.]]
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[[Category: Hao B]]
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[[Category: James, C M.]]
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[[Category: James CM]]
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[[Category: Krzycki, J A.]]
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[[Category: Krzycki JA]]
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[[Category: Tim barrel]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)

PDB ID 1l2q

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