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1ici
From Proteopedia
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| - | {{STRUCTURE_1ici| PDB=1ici | SCENE= }} | ||
| - | ===CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX=== | ||
| - | {{ABSTRACT_PUBMED_11336676}} | ||
| - | == | + | ==CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX== |
| - | [[1ici]] is a 2 chain structure with sequence from [ | + | <StructureSection load='1ici' size='340' side='right'caption='[[1ici]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1ici]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ICI FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ici FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ici OCA], [https://pdbe.org/1ici PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ici RCSB], [https://www.ebi.ac.uk/pdbsum/1ici PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ici ProSAT]</span></td></tr> |
| - | <ref | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NPD1_ARCFU NPD1_ARCFU] NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription (By similarity).<ref>PMID:10841563</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/1ici_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ici ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Archaeoglobus fulgidus]] | [[Category: Archaeoglobus fulgidus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Landry J]] |
| - | [[Category: | + | [[Category: Min J]] |
| - | [[Category: | + | [[Category: Sternglanz R]] |
| - | [[Category: | + | [[Category: Xu R-M]] |
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Current revision
CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX
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