This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1bl8
From Proteopedia
(Difference between revisions)
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_1bl8| PDB=1bl8 | SCENE= }} | ||
| - | ===POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS=== | ||
| - | {{ABSTRACT_PUBMED_9525859}} | ||
| - | == | + | ==POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS== |
| - | [[1bl8]] is a 4 chain structure with sequence from [ | + | <StructureSection load='1bl8' size='340' side='right'caption='[[1bl8]], [[Resolution|resolution]] 3.20Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1bl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. The February 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Potassium Channels'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_2 10.2210/rcsb_pdb/mom_2003_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl8 OCA], [https://pdbe.org/1bl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/1bl8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bl8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Amino Acids|Amino Acids]] | ||
*[[Cation-pi interactions|Cation-pi interactions]] | *[[Cation-pi interactions|Cation-pi interactions]] | ||
*[[Glutamate receptor (GluA2)|Glutamate receptor (GluA2)]] | *[[Glutamate receptor (GluA2)|Glutamate receptor (GluA2)]] | ||
| - | *[[ | + | *[[Ionotropic receptors|Ionotropic receptors]] |
| - | *[[Potassium | + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | < | + | [[Category: Large Structures]] |
[[Category: Potassium Channels]] | [[Category: Potassium Channels]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Streptomyces lividans]] | [[Category: Streptomyces lividans]] | ||
| - | [[Category: Cabral | + | [[Category: Cabral JM]] |
| - | [[Category: Chait | + | [[Category: Chait BT]] |
| - | [[Category: Cohen | + | [[Category: Cohen SL]] |
| - | [[Category: Doyle | + | [[Category: Doyle DA]] |
| - | [[Category: Gulbis | + | [[Category: Gulbis JM]] |
| - | [[Category: Kuo | + | [[Category: Kuo A]] |
| - | [[Category: Mackinnon | + | [[Category: Mackinnon R]] |
| - | [[Category: Pfuetzner | + | [[Category: Pfuetzner RA]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS
| |||||||||||
