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3dxc

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{{STRUCTURE_3dxc| PDB=3dxc | SCENE= }}
 
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===Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2===
 
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{{ABSTRACT_PUBMED_18833287}}
 
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==About this Structure==
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==Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2==
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[[3dxc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXC OCA].
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<StructureSection load='3dxc' size='340' side='right'caption='[[3dxc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dxc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxc OCA], [https://pdbe.org/3dxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxc RCSB], [https://www.ebi.ac.uk/pdbsum/3dxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APBB1_HUMAN APBB1_HUMAN] Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).<ref>PMID:15031292</ref> <ref>PMID:18468999</ref> <ref>PMID:18922798</ref> <ref>PMID:19234442</ref> <ref>PMID:19343227</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dxc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Amyloid precursor protein|Amyloid precursor protein]]
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*[[Amyloid precursor protein 3D structures|Amyloid precursor protein 3D structures]]
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*[[Human APP Intracellular Domain Complex with Fe65-PTB2|Human APP Intracellular Domain Complex with Fe65-PTB2]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018833287</ref><ref group="xtra">PMID:018453713</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Radzimanowski, J.]]
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[[Category: Large Structures]]
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[[Category: Sinning, I.]]
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[[Category: Radzimanowski J]]
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[[Category: Wild, K.]]
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[[Category: Sinning I]]
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[[Category: Aicd]]
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[[Category: Wild K]]
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[[Category: Alzheimer disease]]
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[[Category: Alzheimer's disease]]
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[[Category: Amyloid]]
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[[Category: Apoptosis]]
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[[Category: App]]
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[[Category: Cell adhesion]]
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[[Category: Coated pit]]
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[[Category: Disease mutation]]
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[[Category: Endocytosis]]
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[[Category: Fe65]]
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[[Category: Glycoprotein]]
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[[Category: Heparin-binding]]
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[[Category: Iron]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Notch signaling pathway]]
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[[Category: Phosphoprotein]]
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[[Category: Protease inhibitor]]
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[[Category: Protein binding]]
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[[Category: Proteoglycan]]
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[[Category: Ptb domain]]
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[[Category: Serine protease inhibitor]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2

PDB ID 3dxc

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