4dx8
From Proteopedia
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| - | {{STRUCTURE_4dx8| PDB=4dx8 | SCENE= }} | ||
| - | ===ICAP1 in complex with KRIT1 N-terminus=== | ||
| - | {{ABSTRACT_PUBMED_23317506}} | ||
| - | == | + | ==ICAP1 in complex with KRIT1 N-terminus== |
| - | [[4dx8]] is a 8 chain structure with sequence from [ | + | <StructureSection load='4dx8' size='340' side='right'caption='[[4dx8]], [[Resolution|resolution]] 2.54Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4dx8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DX8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dx8 OCA], [https://pdbe.org/4dx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dx8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ITBP1_HUMAN ITBP1_HUMAN] Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion.[REFERENCE:8] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Boggon | + | [[Category: Large Structures]] |
| - | [[Category: Calderwood | + | [[Category: Boggon TJ]] |
| - | [[Category: Draheim | + | [[Category: Calderwood DA]] |
| - | [[Category: Liu | + | [[Category: Draheim K]] |
| - | [[Category: Zhang | + | [[Category: Liu W]] |
| - | + | [[Category: Zhang R]] | |
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Current revision
ICAP1 in complex with KRIT1 N-terminus
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