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4hxi

From Proteopedia

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{{STRUCTURE_4hxi| PDB=4hxi | SCENE= }}
 
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===Crystal structure of KLHL3/Cul3 complex===
 
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==About this Structure==
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==Crystal structure of KLHL3/Cul3 complex==
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[[4hxi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXI OCA].
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<StructureSection load='4hxi' size='340' side='right'caption='[[4hxi]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hxi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HXI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.513&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hxi OCA], [https://pdbe.org/4hxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hxi RCSB], [https://www.ebi.ac.uk/pdbsum/4hxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hxi ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN] Pseudohypoaldosteronism type 2D. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.<ref>PMID:14528312</ref> <ref>PMID:23387299</ref> <ref>PMID:23453970</ref> <ref>PMID:23665031</ref> <ref>PMID:23576762</ref> <ref>PMID:22406640</ref>
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==See Also==
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*[[Cullin 3D structures|Cullin 3D structures]]
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*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ji, A X.]]
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[[Category: Large Structures]]
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[[Category: Prive, G G.]]
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[[Category: Ji AX]]
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[[Category: Btb-back]]
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[[Category: Prive GG]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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Current revision

Crystal structure of KLHL3/Cul3 complex

PDB ID 4hxi

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