4j5u
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| - | {{STRUCTURE_4j5u| PDB=4j5u | SCENE= }} | ||
| - | ===X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith=== | ||
| - | == | + | ==X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith== |
| - | [[4j5u]] is a 2 chain structure with sequence from [ | + | <StructureSection load='4j5u' size='340' side='right'caption='[[4j5u]], [[Resolution|resolution]] 1.70Å' scene=''> |
| - | [[ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'Sheila_Smith' Rickettsia rickettsii str. 'Sheila Smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5U FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [https://pdbe.org/4j5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [https://www.ebi.ac.uk/pdbsum/4j5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5u ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GLYA_RICRS GLYA_RICRS] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051] |
| + | |||
| + | ==See Also== | ||
| + | *[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rickettsia rickettsii str. 'Sheila Smith']] | ||
Current revision
X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith
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