3hzt

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{{STRUCTURE_3hzt| PDB=3hzt | SCENE= }}
 
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===Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860===
 
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{{ABSTRACT_PUBMED_20436473}}
 
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==About this Structure==
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==Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860==
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[[3hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HZT OCA].
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<StructureSection load='3hzt' size='340' side='right'caption='[[3hzt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hzt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_ME49 Toxoplasma gondii ME49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HZT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J60:5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>J60</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hzt OCA], [https://pdbe.org/3hzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hzt RCSB], [https://www.ebi.ac.uk/pdbsum/3hzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hzt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3HNM6_TOXGO Q3HNM6_TOXGO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/3hzt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hzt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Calcium-dependent protein kinases (CDPKs) have pivotal roles in the calcium-signaling pathway in plants, ciliates and apicomplexan parasites and comprise a calmodulin-dependent kinase (CaMK)-like kinase domain regulated by a calcium-binding domain in the C terminus. To understand this intramolecular mechanism of activation, we solved the structures of the autoinhibited (apo) and activated (calcium-bound) conformations of CDPKs from the apicomplexan parasites Toxoplasma gondii and Cryptosporidium parvum. In the apo form, the C-terminal CDPK activation domain (CAD) resembles a calmodulin protein with an unexpected long helix in the N terminus that inhibits the kinase domain in the same manner as CaMKII. Calcium binding triggers the reorganization of the CAD into a highly intricate fold, leading to its relocation around the base of the kinase domain to a site remote from the substrate binding site. This large conformational change constitutes a distinct mechanism in calcium signal-transduction pathways.
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==Reference==
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Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.,Wernimont AK, Artz JD, Finerty P Jr, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R Nat Struct Mol Biol. 2010 May;17(5):596-601. Epub 2010 May 2. PMID:20436473<ref>PMID:20436473</ref>
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<ref group="xtra">PMID:020436473</ref><references group="xtra"/>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Toxoplasma gondii]]
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</div>
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[[Category: Allali-Hassani, A.]]
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<div class="pdbe-citations 3hzt" style="background-color:#fffaf0;"></div>
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[[Category: Amani, M.]]
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[[Category: Arrowsmith, C H.]]
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==See Also==
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[[Category: Artz, J D.]]
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*[[Calcium-dependent protein kinase|Calcium-dependent protein kinase]]
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[[Category: Bochkarev, A.]]
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== References ==
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[[Category: Bountra, C.]]
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<references/>
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[[Category: Edwards, A M.]]
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__TOC__
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[[Category: Finnerty, P.]]
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</StructureSection>
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[[Category: Hui, R.]]
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[[Category: Large Structures]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Toxoplasma gondii ME49]]
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[[Category: Vedadi, M.]]
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[[Category: Allali-Hassani A]]
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[[Category: Wasney, G.]]
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[[Category: Amani M]]
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[[Category: Weigelt, J.]]
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[[Category: Arrowsmith CH]]
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[[Category: Wernimont, A K.]]
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[[Category: Artz JD]]
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[[Category: Atp-binding]]
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[[Category: Bochkarev A]]
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[[Category: Calcium dependent kinase]]
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[[Category: Bountra C]]
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[[Category: Calmodulin]]
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[[Category: Edwards AM]]
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[[Category: Kinase]]
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[[Category: Finnerty P]]
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[[Category: Nucleotide-binding]]
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[[Category: Hui R]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Vedadi M]]
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[[Category: Sgc]]
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[[Category: Wasney G]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Structural genomics consortium]]
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[[Category: Wernimont AK]]
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[[Category: Transferase]]
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[[Category: Troponin parasite]]
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Current revision

Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860

PDB ID 3hzt

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