3i54

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{{STRUCTURE_3i54| PDB=3i54 | SCENE= }}
 
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===Crystal structure of MtbCRP in complex with cAMP===
 
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{{ABSTRACT_PUBMED_19740754}}
 
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==About this Structure==
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==Crystal structure of MtbCRP in complex with cAMP==
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[[3i54]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I54 OCA].
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<StructureSection load='3i54' size='340' side='right'caption='[[3i54]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3i54]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I54 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i54 OCA], [https://pdbe.org/3i54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i54 RCSB], [https://www.ebi.ac.uk/pdbsum/3i54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i54 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRPL_MYCTU CRPL_MYCTU] Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled.<ref>PMID:15882420</ref> <ref>PMID:20028978</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i54_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i54 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:019740754</ref><references group="xtra"/>
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Bruning, J B.]]
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[[Category: Bruning JB]]
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[[Category: Palaninathan, S K.]]
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[[Category: Palaninathan SK]]
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[[Category: Reddy, M C.]]
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[[Category: Reddy MC]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Smith, D.]]
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[[Category: Smith D]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Thurman C]]
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[[Category: Thurman, C.]]
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[[Category: Allosteric mechanism]]
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[[Category: Camp receptor protein]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein]]
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[[Category: Dna-binding]]
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[[Category: Inhibition]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Crystal structure of MtbCRP in complex with cAMP

PDB ID 3i54

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