3hyr

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{{STRUCTURE_3hyr| PDB=3hyr | SCENE= }}
 
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===Structural Insight into G Protein Coupling and Regulation of Fe2+ Membrane Transport===
 
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{{ABSTRACT_PUBMED_19629046}}
 
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==About this Structure==
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==Structural Insight into G Protein Coupling and Regulation of Fe2+ Membrane Transport==
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[[3hyr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYR OCA].
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<StructureSection load='3hyr' size='340' side='right'caption='[[3hyr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hyr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HYR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hyr OCA], [https://pdbe.org/3hyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hyr RCSB], [https://www.ebi.ac.uk/pdbsum/3hyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hyr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FEOB_ECOLI FEOB_ECOLI] GTP-driven Fe(2+) uptake system.<ref>PMID:8407793</ref> <ref>PMID:12446835</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hyr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hyr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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G proteins are key molecular switches in the regulation of membrane protein function and signal transduction. The prokaryotic membrane protein FeoB is involved in G protein coupled Fe(2+) transport, and is unique in that the G protein is directly tethered to the membrane domain. Here, we report the structure of the soluble domain of FeoB, including the G protein domain, and its assembly into an unexpected trimer. Comparisons between nucleotide free and liganded structures reveal the closed and open state of a central cytoplasmic pore, respectively. In addition, these data provide the first observation of a conformational switch in the nucleotide-binding G5 motif, defining the structural basis for GDP release. From these results, structural parallels are drawn to eukaryotic G protein coupled membrane processes.
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==Reference==
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Structural basis of GDP release and gating in G protein coupled Fe2+ transport.,Guilfoyle A, Maher MJ, Rapp M, Clarke R, Harrop S, Jormakka M EMBO J. 2009 Sep 2;28(17):2677-85. Epub 2009 Jul 23. PMID:19629046<ref>PMID:19629046</ref>
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<ref group="xtra">PMID:019629046</ref><references group="xtra"/>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3hyr" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Jormakka, M.]]
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[[Category: Large Structures]]
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[[Category: Maher, M J.]]
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[[Category: Jormakka M]]
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[[Category: Cell inner membrane]]
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[[Category: Maher MJ]]
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[[Category: Cell membrane]]
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[[Category: G protein]]
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[[Category: Gtp-binding]]
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[[Category: Ion transport]]
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[[Category: Iron]]
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[[Category: Iron transport]]
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[[Category: Membrane]]
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[[Category: Metal transport]]
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[[Category: Nucleotide-binding]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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Structural Insight into G Protein Coupling and Regulation of Fe2+ Membrane Transport

PDB ID 3hyr

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