3hif
From Proteopedia
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| - | {{STRUCTURE_3hif| PDB=3hif | SCENE= }} | ||
| - | ===The crystal structure of apo wild type CAP at 3.6 A resolution.=== | ||
| - | {{ABSTRACT_PUBMED_19805344}} | ||
| - | == | + | ==The crystal structure of apo wild type CAP at 3.6 A resolution.== |
| - | [[3hif]] is a 6 chain structure with sequence from [ | + | <StructureSection load='3hif' size='340' side='right'caption='[[3hif]], [[Resolution|resolution]] 3.59Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3hif]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HIF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.59Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hif OCA], [https://pdbe.org/3hif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hif RCSB], [https://www.ebi.ac.uk/pdbsum/3hif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hif ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/3hif_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hif ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Kong | + | [[Category: Large Structures]] |
| - | [[Category: Sharma | + | [[Category: Kong J]] |
| - | [[Category: Steitz | + | [[Category: Sharma H]] |
| - | [[Category: Wang | + | [[Category: Steitz TA]] |
| - | [[Category: Yu | + | [[Category: Wang J]] |
| - | + | [[Category: Yu S]] | |
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Current revision
The crystal structure of apo wild type CAP at 3.6 A resolution.
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Categories: Escherichia coli | Large Structures | Kong J | Sharma H | Steitz TA | Wang J | Yu S
