3ifi
From Proteopedia
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| - | {{STRUCTURE_3ifi| PDB=3ifi | SCENE= }} | ||
| - | ===2'-SeMe-dG modified octamer DNA=== | ||
| - | {{ABSTRACT_PUBMED_20047333}} | ||
| - | == | + | ==2'-SeMe-dG modified octamer DNA== |
| - | [[3ifi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFI OCA]. | + | <StructureSection load='3ifi' size='340' side='right'caption='[[3ifi]], [[Resolution|resolution]] 1.20Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ifi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IFI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XUG:2-SE-METHYL-2-SELENOGUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>XUG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ifi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifi OCA], [https://pdbe.org/3ifi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ifi RCSB], [https://www.ebi.ac.uk/pdbsum/3ifi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Selenium modification of nucleic acids is of great importance in X-ray crystal structure determination and functional study of nucleic acids. Herein, we describe a convenient synthesis of a new building block, the 2'-SeMe-modified guanosine (G(Se)) phosphoramidite, and report the first incorporation of the 2'-Se-G moiety into DNA. The X-ray crystal structure of the 2'-Se-modified octamer DNA (5'-GTG(Se)TACAC-3') was determined at a resolution of 1.20 A. We also found that the 2'-Se modification points to the minor groove and that the modified and native structures are virtually identical. Furthermore, we observed that the 2'-Se-G modification can significantly facilitate the crystal growth with respect to the corresponding native DNA. | ||
| - | + | Synthesis and crystal structure of 2'-se-modified guanosine containing DNA.,Salon J, Sheng J, Gan J, Huang Z J Org Chem. 2010 Feb 5;75(3):637-41. PMID:20047333<ref>PMID:20047333</ref> | |
| - | <ref | + | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 3ifi" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| + | [[Category: Gan J]] | ||
| + | [[Category: Huang Z]] | ||
| + | [[Category: Salon J]] | ||
| + | [[Category: Sheng J]] | ||
Current revision
2'-SeMe-dG modified octamer DNA
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Categories: Large Structures | Gan J | Huang Z | Salon J | Sheng J
