3i4h

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{{STRUCTURE_3i4h| PDB=3i4h | SCENE= }}
 
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===Crystal structure of Cas6 in Pyrococcus furiosus===
 
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{{ABSTRACT_PUBMED_19141480}}
 
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==About this Structure==
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==Crystal structure of Cas6 in Pyrococcus furiosus==
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[[3i4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4H OCA].
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<StructureSection load='3i4h' size='340' side='right'caption='[[3i4h]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3i4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I4H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4h OCA], [https://pdbe.org/3i4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i4h RCSB], [https://www.ebi.ac.uk/pdbsum/3i4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i4h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAS6_PYRFU CAS6_PYRFU] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism. This protein processes pre-crRNA into individual crRNA units, with an 8-nt 5'-repeat DNA tag that may help other proteins recognize the crRNA. Further processing occurs at their 3' termini in this organism. Generates a 5'-hydroxy and 2',3'-cyclic phosphodiester.<ref>PMID:19141480</ref> <ref>PMID:20884784</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/3i4h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i4h ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:019141480</ref><references group="xtra"/>
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*[[CRISPR subtype III-B (Cmr complex)|CRISPR subtype III-B (Cmr complex)]]
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*[[CRISPR-Cas|CRISPR-Cas]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Carte, J.]]
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[[Category: Carte J]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: Terns, M P.]]
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[[Category: Terns MP]]
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[[Category: Terns, R M.]]
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[[Category: Terns RM]]
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[[Category: Wang, R.]]
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[[Category: Wang R]]
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[[Category: Endoribonuclease]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of Cas6 in Pyrococcus furiosus

PDB ID 3i4h

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