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1dq8

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{{STRUCTURE_1dq8| PDB=1dq8 | SCENE= }}
 
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===COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA===
 
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{{ABSTRACT_PUBMED_10698924}}
 
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==About this Structure==
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==COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA==
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[[1dq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ8 OCA].
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<StructureSection load='1dq8' size='340' side='right'caption='[[1dq8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MAH:3-HYDROXY-3-METHYL-GLUTARIC+ACID'>MAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq8 OCA], [https://pdbe.org/1dq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1dq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dq8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dq8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dq8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[G13SecL03Tpc3|G13SecL03Tpc3]]
 
*[[HMG-CoA Reductase|HMG-CoA Reductase]]
*[[HMG-CoA Reductase|HMG-CoA Reductase]]
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*[[Molecular Playground/4'-PHOSPHOPANTETHEINYL TRANSFERASE (Sfp)|Molecular Playground/4'-PHOSPHOPANTETHEINYL TRANSFERASE (Sfp)]]
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*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
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*[[Sand box 465|Sand box 465]]
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__TOC__
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*[[Zhe Zhang|Zhe Zhang]]
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:010698924</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Buchanan, S K.]]
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[[Category: Large Structures]]
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[[Category: Deisenhofer, J.]]
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[[Category: Buchanan SK]]
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[[Category: Istvan, E S.]]
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[[Category: Deisenhofer J]]
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[[Category: Palnitkar, M.]]
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[[Category: Istvan ES]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Palnitkar M]]
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[[Category: Hmg-coa]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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Current revision

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA

PDB ID 1dq8

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