2aoa

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{{STRUCTURE_2aoa| PDB=2aoa | SCENE= }}
 
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===Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain===
 
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{{ABSTRACT_PUBMED_16165154}}
 
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==About this Structure==
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==Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain==
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[[2aoa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOA OCA].
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<StructureSection load='2aoa' size='340' side='right'caption='[[2aoa]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2aoa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AOA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=S1S:2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC+ACID'>S1S</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aoa OCA], [https://pdbe.org/2aoa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aoa RCSB], [https://www.ebi.ac.uk/pdbsum/2aoa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aoa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ao/2aoa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aoa ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Growth factor receptor-bound protein|Growth factor receptor-bound protein]]
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016165154</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Burke, T R.]]
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[[Category: Large Structures]]
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[[Category: Phan, J.]]
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[[Category: Burke TR]]
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[[Category: Shi, Z D.]]
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[[Category: Phan J]]
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[[Category: Waugh, D S.]]
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[[Category: Shi ZD]]
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[[Category: Domain-swapped]]
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[[Category: Waugh DS]]
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[[Category: Grb2 sh2]]
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[[Category: Peptide mimetic]]
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[[Category: Transferase]]
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Current revision

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

PDB ID 2aoa

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