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2m5y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution Structure of the C-terminal domain of RV0431== | |
| + | <StructureSection load='2m5y' size='340' side='right'caption='[[2m5y]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2m5y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M5Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5y OCA], [https://pdbe.org/2m5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m5y RCSB], [https://www.ebi.ac.uk/pdbsum/2m5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m5y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator." | ||
| - | + | Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.,Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4790-7. doi:, 10.1073/pnas.1320118110. Epub 2013 Nov 18. PMID:24248369<ref>PMID:24248369</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2m5y" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Huang C]] | ||
| + | [[Category: Li H]] | ||
| + | [[Category: Wang T]] | ||
Current revision
Solution Structure of the C-terminal domain of RV0431
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