This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3q6g
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_3q6g| PDB=3q6g | SCENE= }} | ||
| - | ===Crystal structure of Fab of rhesus mAb 2.5B specific for quaternary neutralizing epitope of HIV-1 gp120=== | ||
| - | {{ABSTRACT_PUBMED_21565703}} | ||
| - | == | + | ==Crystal structure of Fab of rhesus mAb 2.5B specific for quaternary neutralizing epitope of HIV-1 gp120== |
| - | [[3q6g]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3q6g' size='340' side='right'caption='[[3q6g]], [[Resolution|resolution]] 1.90Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3q6g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q6G FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q6f|3q6f]]</div></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6g OCA], [https://pdbe.org/3q6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q6g RCSB], [https://www.ebi.ac.uk/pdbsum/3q6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q6g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The quaternary neutralizing epitope (QNE) of HIV-1 gp120 is preferentially expressed on the trimeric envelope spikes of intact HIV virions, and QNE-specific monoclonal antibodies (mAbs) potently neutralize HIV-1. Here, we present the crystal structures of the Fabs of human mAb 2909 and macaque mAb 2.5B. Both mAbs have long beta hairpin CDR H3 regions >20 A in length that are each situated at the center of their respective antigen-binding sites. Computational analysis showed that the paratopes include the whole CDR H3, while additional CDR residues form shallow binding pockets. Structural modeling suggests a way to understand the configuration of QNEs and the antigen-antibody interaction for QNE mAbs. Our data will be useful in designing immunogens that may elicit potent neutralizing QNE Abs. | ||
| - | + | Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120.,Spurrier B, Sampson JM, Totrov M, Li H, O'Neal T, Williams C, Robinson J, Gorny MK, Zolla-Pazner S, Kong XP Structure. 2011 May 11;19(5):691-9. PMID:21565703<ref>PMID:21565703</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| + | <div class="pdbe-citations 3q6g" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Macaca mulatta]] | [[Category: Macaca mulatta]] | ||
| - | [[Category: Gorny, M K | + | [[Category: Gorny, M K]] |
| - | [[Category: Kong, X P | + | [[Category: Kong, X P]] |
| - | [[Category: Li, H | + | [[Category: Li, H]] |
| - | [[Category: Neal, T O | + | [[Category: Neal, T O]] |
| - | [[Category: Robinson, J | + | [[Category: Robinson, J]] |
| - | [[Category: Sampson, J | + | [[Category: Sampson, J]] |
| - | [[Category: Spurrier, B | + | [[Category: Spurrier, B]] |
| - | [[Category: Totrov, M | + | [[Category: Totrov, M]] |
| - | [[Category: William, C | + | [[Category: William, C]] |
| - | [[Category: Zolla-Pazner, S | + | [[Category: Zolla-Pazner, S]] |
[[Category: Ig]] | [[Category: Ig]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Neutralization of hiv-1 viruse]] | [[Category: Neutralization of hiv-1 viruse]] | ||
[[Category: Quaternary epitope of hiv-1 gp120]] | [[Category: Quaternary epitope of hiv-1 gp120]] | ||
Current revision
Crystal structure of Fab of rhesus mAb 2.5B specific for quaternary neutralizing epitope of HIV-1 gp120
| |||||||||||
