Cobra venom factor
From Proteopedia
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| - | '''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites. | + | <StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='350' side='right' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'> |
| - | + | '''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.<ref>PMID:15159065</ref> | |
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===Structure=== | ===Structure=== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[3pvm]] – CVF + hComplement C5 <br /> | + | [[3pvm]], [[8ayh]] – CVF + hComplement C5 <br /> |
[[3frp]] – CVF α,β,γ chains <br /> | [[3frp]] – CVF α,β,γ chains <br /> | ||
[[3hrz]] – CVF α,β,γ chains + hComplement C5 (mutant)<br /> | [[3hrz]] – CVF α,β,γ chains + hComplement C5 (mutant)<br /> | ||
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[[3prx]] – CVF α,β,γ chains + hComplement C5 + superantigen-like protein 7<br /> | [[3prx]] – CVF α,β,γ chains + hComplement C5 + superantigen-like protein 7<br /> | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Cobra venom factor
Updated on 21-December-2022
3pvm, 8ayh – CVF + hComplement C5
3frp – CVF α,β,γ chains
3hrz – CVF α,β,γ chains + hComplement C5 (mutant)
3hs0 – CVF α,β,γ chains + hComplement B (mutant)
3prx – CVF α,β,γ chains + hComplement C5 + superantigen-like protein 7
References
- ↑ Vogel CW, Fritzinger DC, Hew BE, Thorne M, Bammert H. Recombinant cobra venom factor. Mol Immunol. 2004 Jun;41(2-3):191-9. PMID:15159065 doi:http://dx.doi.org/10.1016/j.molimm.2004.03.011
- ↑ Krishnan V, Ponnuraj K, Xu Y, Macon K, Volanakis JE, Narayana SV. The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb. Structure. 2009 Apr 15;17(4):611-9. PMID:19368894 doi:10.1016/j.str.2009.01.015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Gary A. Toumas, Alexander Berchansky, Joel L. Sussman
