4gsv
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| - | {{STRUCTURE_4gsv| PDB=4gsv | SCENE= }} | ||
| - | ===Crystal Structure of the Ni2+2-Human Arginase I-ABH complex=== | ||
| - | {{ABSTRACT_PUBMED_23061982}} | ||
| - | == | + | ==Crystal Structure of the Ni2+2-Human Arginase I-ABH complex== |
| - | [[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN | + | <StructureSection load='4gsv' size='340' side='right'caption='[[4gsv]], [[Resolution|resolution]] 1.48Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsv OCA], [https://pdbe.org/4gsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsv RCSB], [https://www.ebi.ac.uk/pdbsum/4gsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Arginase 3D structures|Arginase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Christianson | + | [[Category: Christianson DW]] |
| - | [[Category: | + | [[Category: D'Antonio EL]] |
| - | [[Category: | + | [[Category: Hai Y]] |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of the Ni2+2-Human Arginase I-ABH complex
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