1z2a

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{{STRUCTURE_1z2a| PDB=1z2a | SCENE= }}
 
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===GDP-Bound Rab23 GTPase crystallized in P2(1)2(1)2(1) space group===
 
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{{ABSTRACT_PUBMED_16034420}}
 
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==Disease==
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==GDP-Bound Rab23 GTPase crystallized in P2(1)2(1)2(1) space group==
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[[http://www.uniprot.org/uniprot/RAB23_MOUSE RAB23_MOUSE]] Note=Defects in Rab23 are the cause of the open brain phenotype. Mice suffer from exencephaly and severe malformations of the spinal cord and the dorsal root ganglia, leading to complete embryonic lethality. In addition, mice display poorly developed eyes and polydactyly.<ref>PMID:7720556</ref>
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<StructureSection load='1z2a' size='340' side='right'caption='[[1z2a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z2A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2a OCA], [https://pdbe.org/1z2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z2a RCSB], [https://www.ebi.ac.uk/pdbsum/1z2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2a ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RAB23_MOUSE RAB23_MOUSE] Note=Defects in Rab23 are the cause of the open brain phenotype. Mice suffer from exencephaly and severe malformations of the spinal cord and the dorsal root ganglia, leading to complete embryonic lethality. In addition, mice display poorly developed eyes and polydactyly.<ref>PMID:7720556</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB23_MOUSE RAB23_MOUSE] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity). Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity.<ref>PMID:7720556</ref> <ref>PMID:11071781</ref> <ref>PMID:11449277</ref> <ref>PMID:16364285</ref> <ref>PMID:18218620</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z2a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z2a ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/RAB23_MOUSE RAB23_MOUSE]] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity). Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity.<ref>PMID:7720556</ref><ref>PMID:11071781</ref><ref>PMID:11449277</ref><ref>PMID:16364285</ref><ref>PMID:18218620</ref>
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1z2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2A OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:016034420</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Eathiraj, S.]]
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[[Category: Eathiraj S]]
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[[Category: Lambright, D G.]]
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[[Category: Lambright DG]]
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[[Category: Pan, X.]]
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[[Category: Pan X]]
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[[Category: Ritacco, C.]]
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[[Category: Ritacco C]]
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[[Category: Protein transport]]
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[[Category: Rab gtpase]]
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[[Category: Rab23]]
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[[Category: Vesicular trafficking]]
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Current revision

GDP-Bound Rab23 GTPase crystallized in P2(1)2(1)2(1) space group

PDB ID 1z2a

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