1et2
From Proteopedia
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{{Theoretical_model}} | {{Theoretical_model}} | ||
| - | + | ==MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.== | |
| - | + | <StructureSection load='1et2' size='340' side='right'caption='[[1et2]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ET2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1et2 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1et2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1et2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroid hormone-related peptide (PTHrP), act on cells via a common PTH/PTHrP receptor. To define more precisely the ligand-receptor interactions, we have crystallized human PTH (hPTH)-(1-34) and determined the structure to 0.9-A resolution. hPTH-(1-34) crystallizes as a slightly bent, long helical dimer. Analysis reveals that the extended helical conformation of hPTH-(1-34) is the likely bioactive conformation. We have developed molecular models for the interaction of hPTH-(1-34) and hPTHrP-(1-34) with the PTH/PTHrP receptor. A receptor binding pocket for the N terminus of hPTH-(1-34) and a hydrophobic interface with the receptor for the C terminus of hPTH-(1-34) are proposed. | ||
| - | + | Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.,Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F J Biol Chem. 2000 Sep 1;275(35):27238-44. PMID:10837469<ref>PMID:10837469</ref> | |
| - | <ref | + | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 1et2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Briggs, S L]] | [[Category: Briggs, S L]] | ||
[[Category: Chandrasekhar, S]] | [[Category: Chandrasekhar, S]] | ||
Current revision
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MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.
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