1q6k
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_1q6k| PDB=1q6k | SCENE= }} | ||
| - | ===Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate=== | ||
| - | {{ABSTRACT_PUBMED_14684342}} | ||
| - | == | + | ==Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate== |
| - | [[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN | + | <StructureSection load='1q6k' size='340' side='right'caption='[[1q6k]], [[Resolution|resolution]] 2.10Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1q6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q6K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCO:TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE'>TCO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6k OCA], [https://pdbe.org/1q6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q6k RCSB], [https://www.ebi.ac.uk/pdbsum/1q6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q6k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/1q6k_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q6k ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM. | ||
| - | + | Exploration of the P1 SAR of aldehyde cathepsin K inhibitors.,Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH Jr, Wright LL Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. PMID:14684342<ref>PMID:14684342</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 1q6k" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Cathepsin|Cathepsin]] | + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Catalano | + | [[Category: Large Structures]] |
| - | [[Category: Deaton | + | [[Category: Catalano JG]] |
| - | [[Category: Furfine | + | [[Category: Deaton DN]] |
| - | [[Category: Hassell | + | [[Category: Furfine ES]] |
| - | [[Category: McFadyen | + | [[Category: Hassell AM]] |
| - | [[Category: Miller | + | [[Category: McFadyen RB]] |
| - | [[Category: Miller | + | [[Category: Miller AB]] |
| - | [[Category: Shewchuk | + | [[Category: Miller LR]] |
| - | [[Category: Willard | + | [[Category: Shewchuk LM]] |
| - | [[Category: Wright | + | [[Category: Willard DH]] |
| - | + | [[Category: Wright LL]] | |
| - | + | ||
| - | + | ||
Current revision
Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate
| |||||||||||
Categories: Homo sapiens | Large Structures | Catalano JG | Deaton DN | Furfine ES | Hassell AM | McFadyen RB | Miller AB | Miller LR | Shewchuk LM | Willard DH | Wright LL
