1ujy

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{{STRUCTURE_1ujy| PDB=1ujy | SCENE= }}
 
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===Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6===
 
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==Disease==
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==Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6==
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[[http://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN]] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[http://omim.org/entry/300436 300436]]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref>
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<StructureSection load='1ujy' size='340' side='right'caption='[[1ujy]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ujy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujy OCA], [https://pdbe.org/1ujy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujy RCSB], [https://www.ebi.ac.uk/pdbsum/1ujy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujy ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujy TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[https://omim.org/entry/300436 300436]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ujy ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN]] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
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*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1ujy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aoki, M.]]
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[[Category: Large Structures]]
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[[Category: He, F.]]
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[[Category: Aoki M]]
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[[Category: Hirota, H.]]
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[[Category: He F]]
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[[Category: Inoue, M.]]
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[[Category: Hirota H]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Kikuno, R.]]
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[[Category: Kigawa T]]
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[[Category: Kobayashi, N.]]
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[[Category: Kikuno R]]
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[[Category: Koshiba, S.]]
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[[Category: Kobayashi N]]
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[[Category: Matsuda, T.]]
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[[Category: Koshiba S]]
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[[Category: Matsuo, Y.]]
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[[Category: Matsuda T]]
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[[Category: Muto, Y.]]
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[[Category: Matsuo Y]]
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[[Category: Nagase, T.]]
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[[Category: Muto Y]]
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[[Category: Nagayama, M.]]
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[[Category: Nagase T]]
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[[Category: Ohara, O.]]
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[[Category: Nagayama M]]
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[[Category: Osanai, T.]]
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[[Category: Ohara O]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Osanai T]]
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[[Category: Seki, E.]]
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[[Category: Seki E]]
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[[Category: Shirouzu, M.]]
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[[Category: Shirouzu M]]
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[[Category: Tanaka, A.]]
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[[Category: Tanaka A]]
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[[Category: Terada, T.]]
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[[Category: Terada T]]
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[[Category: Uda, H.]]
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[[Category: Uda H]]
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[[Category: Yabuki, T.]]
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[[Category: Yabuki T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Yoshida, M.]]
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[[Category: Yoshida M]]
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[[Category: Gef 6]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6

PDB ID 1ujy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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