3d5q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:40, 21 February 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3d5q| PDB=3d5q | SCENE= }}
 
-
===Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor===
 
-
{{ABSTRACT_PUBMED_18789704}}
 
-
==Disease==
+
==Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor==
-
[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
+
<StructureSection load='3d5q' size='340' side='right'caption='[[3d5q]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[3d5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D5Q FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=T30:3-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-(1-METHYLETHYL)-5-[4-(TRIFLUOROMETHOXY)PHENYL]-4H-1,2,4-TRIAZOLE'>T30</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d5q OCA], [https://pdbe.org/3d5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d5q RCSB], [https://www.ebi.ac.uk/pdbsum/3d5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d5q ProSAT]</span></td></tr>
-
[[3d5q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D5Q OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/3d5q_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d5q ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
+
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:018789704</ref><references group="xtra"/><references/>
+
-
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Liu, J.]]
+
[[Category: Large Structures]]
-
[[Category: Sudom, A.]]
+
[[Category: Liu J]]
-
[[Category: Walker, N P.C.]]
+
[[Category: Sudom A]]
-
[[Category: Wang, Z.]]
+
[[Category: Walker NPC]]
-
[[Category: 11beta]]
+
[[Category: Wang Z]]
-
[[Category: Dehydrogenase]]
+
-
[[Category: Endoplasmic reticulum]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Hydroxysteroid]]
+
-
[[Category: Lipid metabolism]]
+
-
[[Category: Membrane]]
+
-
[[Category: Microsome]]
+
-
[[Category: Nadp]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Signal-anchor]]
+
-
[[Category: Steroid metabolism]]
+
-
[[Category: Transmembrane]]
+

Current revision

Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor

PDB ID 3d5q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3d5q"
Personal tools