1z8d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:05, 23 August 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1z8d| PDB=1z8d | SCENE= }}
 
-
===Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose===
 
-
==Disease==
+
==Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose==
-
[[http://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN]] Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:[http://omim.org/entry/232600 232600]]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.<ref>PMID:8316268</ref><ref>PMID:8535454</ref><ref>PMID:7603523</ref><ref>PMID:9506549</ref><ref>PMID:10417800</ref><ref>PMID:10382911</ref><ref>PMID:10382912</ref><ref>PMID:10681080</ref><ref>PMID:10590419</ref><ref>PMID:10714589</ref><ref>PMID:10899452</ref><ref>PMID:11706962</ref><ref>PMID:12031624</ref>
+
<StructureSection load='1z8d' size='340' side='right'caption='[[1z8d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[1z8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8D FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8d OCA], [https://pdbe.org/1z8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8d RCSB], [https://www.ebi.ac.uk/pdbsum/1z8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8d ProSAT]</span></td></tr>
-
[[1z8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:[https://omim.org/entry/232600 232600]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.<ref>PMID:8316268</ref> <ref>PMID:8535454</ref> <ref>PMID:7603523</ref> <ref>PMID:9506549</ref> <ref>PMID:10417800</ref> <ref>PMID:10382911</ref> <ref>PMID:10382912</ref> <ref>PMID:10681080</ref> <ref>PMID:10590419</ref> <ref>PMID:10714589</ref> <ref>PMID:10899452</ref> <ref>PMID:11706962</ref> <ref>PMID:12031624</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8d_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8d ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Glycogen Phosphorylase|Glycogen Phosphorylase]]
+
*[[Glycogen phosphorylase 3D structures|Glycogen phosphorylase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:016523484</ref><references group="xtra"/><references/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Phosphorylase]]
+
[[Category: Large Structures]]
-
[[Category: Crowther, R L.]]
+
[[Category: Crowther RL]]
-
[[Category: Hong, L N.]]
+
[[Category: Hong LN]]
-
[[Category: Kammlott, R U.]]
+
[[Category: Kammlott RU]]
-
[[Category: Levin, W.]]
+
[[Category: Levin W]]
-
[[Category: Li, S.]]
+
[[Category: Li S]]
-
[[Category: Liu, C M.]]
+
[[Category: Liu CM]]
-
[[Category: Lucas-McGady, D.]]
+
[[Category: Lucas-McGady D]]
-
[[Category: Lukacs, C M.]]
+
[[Category: Lukacs CM]]
-
[[Category: Oikonomakos, N G.]]
+
[[Category: Oikonomakos NG]]
-
[[Category: Pietranico, S.]]
+
[[Category: Pietranico S]]
-
[[Category: Reik, L.]]
+
[[Category: Reik L]]
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose

PDB ID 1z8d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z8d"
Personal tools