3swv

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{{STRUCTURE_3swv| PDB=3swv | SCENE= }}
 
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===Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) from Homo sapiens (Human), Northeast Structural Genomics Consortium target id HR5562A===
 
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==Disease==
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==Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) from Homo sapiens (Human), Northeast Structural Genomics Consortium target id HR5562A==
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[[http://www.uniprot.org/uniprot/BIG2_HUMAN BIG2_HUMAN]] Defects in ARFGEF2 are the cause of autosomal recessive periventricular nodular heterotopia type 2 (PVNH2) [MIM:[http://omim.org/entry/608097 608097]]; also known as periventricular heterotopia with microcephaly autosomal recessive. PVNH is a developmental disorder characterized by the presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH2 is an autosomal recessive form characterized by microcephaly (small brain), severe developmental delay and recurrent infections. No anomalies extrinsic to the central nervous system, such as dysmorphic features or grossly abnormal endocrine or other conditions, are associated with PVNH2.<ref>PMID:14647276</ref>
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<StructureSection load='3swv' size='340' side='right'caption='[[3swv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3swv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SWV FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/BIG2_HUMAN BIG2_HUMAN]] Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.<ref>PMID:12051703</ref><ref>PMID:12571360</ref><ref>PMID:15385626</ref><ref>PMID:16477018</ref><ref>PMID:17276987</ref><ref>PMID:18625701</ref><ref>PMID:20360857</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3swv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swv OCA], [https://pdbe.org/3swv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3swv RCSB], [https://www.ebi.ac.uk/pdbsum/3swv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3swv ProSAT]</span></td></tr>
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[[3swv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWV OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/BIG2_HUMAN BIG2_HUMAN] Defects in ARFGEF2 are the cause of autosomal recessive periventricular nodular heterotopia type 2 (PVNH2) [MIM:[https://omim.org/entry/608097 608097]; also known as periventricular heterotopia with microcephaly autosomal recessive. PVNH is a developmental disorder characterized by the presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH2 is an autosomal recessive form characterized by microcephaly (small brain), severe developmental delay and recurrent infections. No anomalies extrinsic to the central nervous system, such as dysmorphic features or grossly abnormal endocrine or other conditions, are associated with PVNH2.<ref>PMID:14647276</ref>
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<references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/BIG2_HUMAN BIG2_HUMAN] Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.<ref>PMID:12051703</ref> <ref>PMID:12571360</ref> <ref>PMID:15385626</ref> <ref>PMID:16477018</ref> <ref>PMID:17276987</ref> <ref>PMID:18625701</ref> <ref>PMID:20360857</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Baran, M C.]]
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[[Category: Acton TB]]
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[[Category: Cunningham, K.]]
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[[Category: Baran MC]]
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[[Category: Forouhar, F.]]
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[[Category: Cunningham K]]
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[[Category: Hunt, J F.]]
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[[Category: Forouhar F]]
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[[Category: Janjua, H.]]
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[[Category: Hunt JF]]
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[[Category: Liu, J.]]
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[[Category: Janjua H]]
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[[Category: Montelione, G T.]]
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[[Category: Liu J]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Owens, L.]]
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[[Category: Owens L]]
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[[Category: Seetharaman, J.]]
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[[Category: Seetharaman J]]
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[[Category: Su, M.]]
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[[Category: Su M]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Wang, D.]]
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[[Category: Wang D]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding protein]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Nucleotide-binding protein]]
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[[Category: Phosphoprotein]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) from Homo sapiens (Human), Northeast Structural Genomics Consortium target id HR5562A

PDB ID 3swv

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