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1t3g

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{{STRUCTURE_1t3g| PDB=1t3g | SCENE= }}
 
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===Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL===
 
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{{ABSTRACT_PUBMED_15123616}}
 
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==Disease==
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==Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL==
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[[http://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN]] Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:[http://omim.org/entry/300143 300143]]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:10757639</ref><ref>PMID:16470793</ref>
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<StructureSection load='1t3g' size='340' side='right'caption='[[1t3g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1t3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3G FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN]] May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.<ref>PMID:12783849</ref><ref>PMID:15123616</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3g OCA], [https://pdbe.org/1t3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3g RCSB], [https://www.ebi.ac.uk/pdbsum/1t3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3g ProSAT]</span></td></tr>
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[[1t3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN] Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:[https://omim.org/entry/300143 300143]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:10757639</ref> <ref>PMID:16470793</ref>
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<ref group="xtra">PMID:015123616</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN] May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.<ref>PMID:12783849</ref> <ref>PMID:15123616</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3g ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Khan, J A.]]
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[[Category: Large Structures]]
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[[Category: Tong, L.]]
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[[Category: Khan JA]]
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[[Category: Il-1r]]
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[[Category: Tong L]]
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[[Category: Il-1rapl]]
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[[Category: Membrane protein]]
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[[Category: Tir]]
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[[Category: Tlr]]
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Current revision

Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL

PDB ID 1t3g

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