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1trn

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{{STRUCTURE_1trn| PDB=1trn | SCENE= }}
 
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===CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151===
 
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{{ABSTRACT_PUBMED_8683601}}
 
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==Disease==
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==CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151==
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[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Defects in PRSS1 are a cause of pancreatitis (PCTT) [MIM:[http://omim.org/entry/167800 167800]]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.<ref>PMID:10930381</ref><ref>PMID:8841182</ref><ref>PMID:11866271</ref><ref>PMID:9322498</ref><ref>PMID:9633818</ref><ref>PMID:10381903</ref><ref>PMID:10204851</ref><ref>PMID:11073545</ref><ref>PMID:11788572</ref><ref>PMID:14695529</ref><ref>PMID:15776435</ref>
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<StructureSection load='1trn' size='340' side='right'caption='[[1trn]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1trn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TRN FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.<ref>PMID:7945238</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ISP:PHOSPHORYLISOPROPANE'>ISP</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1trn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1trn OCA], [https://pdbe.org/1trn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1trn RCSB], [https://www.ebi.ac.uk/pdbsum/1trn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1trn ProSAT]</span></td></tr>
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[[1trn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TRN OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN] Defects in PRSS1 are a cause of pancreatitis (PCTT) [MIM:[https://omim.org/entry/167800 167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.<ref>PMID:10930381</ref> <ref>PMID:8841182</ref> <ref>PMID:11866271</ref> <ref>PMID:9322498</ref> <ref>PMID:9633818</ref> <ref>PMID:10381903</ref> <ref>PMID:10204851</ref> <ref>PMID:11073545</ref> <ref>PMID:11788572</ref> <ref>PMID:14695529</ref> <ref>PMID:15776435</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN] Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.<ref>PMID:7945238</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/1trn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1trn ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Trypsin|Trypsin]]
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008683601</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Trypsin]]
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[[Category: Large Structures]]
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[[Category: Fontecilla-Camps, J C.]]
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[[Category: Fontecilla-Camps JC]]
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[[Category: Gaboriaud, C.]]
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[[Category: Gaboriaud C]]
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[[Category: Dfp inhibited]]
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[[Category: Human trypsin]]
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CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151

PDB ID 1trn

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