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3tkb
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| - | {{STRUCTURE_3tkb| PDB=3tkb | SCENE= }} | ||
| - | ===crystal structure of human uracil-DNA glycosylase D183G/K302R mutant=== | ||
| - | {{ABSTRACT_PUBMED_21959147}} | ||
| - | == | + | ==crystal structure of human uracil-DNA glycosylase D183G/K302R mutant== |
| - | [[http://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN | + | <StructureSection load='3tkb' size='340' side='right'caption='[[3tkb]], [[Resolution|resolution]] 1.50Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TKB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tkb OCA], [https://pdbe.org/3tkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tkb RCSB], [https://www.ebi.ac.uk/pdbsum/3tkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tkb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN] Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5) [MIM:[https://omim.org/entry/608106 608106]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:12958596</ref> <ref>PMID:15967827</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | |
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Assefa | + | [[Category: Assefa NG]] |
| - | [[Category: Moe | + | [[Category: Moe E]] |
| - | [[Category: Niiranen | + | [[Category: Niiranen L]] |
| - | [[Category: Smalas | + | [[Category: Smalas AO]] |
| - | [[Category: Willassen | + | [[Category: Willassen NP]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
crystal structure of human uracil-DNA glycosylase D183G/K302R mutant
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