1nax

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{{STRUCTURE_1nax| PDB=1nax | SCENE= }}
 
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===Thyroid receptor beta1 in complex with a beta-selective ligand===
 
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{{ABSTRACT_PUBMED_12699376}}
 
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==Disease==
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==Thyroid receptor beta1 in complex with a beta-selective ligand==
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[[http://www.uniprot.org/uniprot/THB_HUMAN THB_HUMAN]] Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:[http://omim.org/entry/188570 188570]]. GTHR is a disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).<ref>PMID:2510172</ref><ref>PMID:2153155</ref><ref>PMID:1846005</ref><ref>PMID:1661299</ref><ref>PMID:1653889</ref><ref>PMID:1563081</ref><ref>PMID:1314846</ref><ref>PMID:1619012</ref><ref>PMID:1587388</ref><ref>PMID:1324420</ref><ref>PMID:8514853</ref><ref>PMID:8175986</ref><ref>PMID:7833659</ref><ref>PMID:8664910</ref><ref>PMID:8889584</ref><ref>PMID:10660344</ref><ref>PMID:16804041</ref><ref>PMID:19268523</ref> Defects in THRB are the cause of generalized thyroid hormone resistance autosomal recessive (GTHRAR) [MIM:[http://omim.org/entry/274300 274300]]. An autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone. Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:[http://omim.org/entry/145650 145650]]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.<ref>PMID:7528740</ref><ref>PMID:8381821</ref>
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<StructureSection load='1nax' size='340' side='right'caption='[[1nax]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NAX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IH5:{3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC+ACID'>IH5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nax OCA], [https://pdbe.org/1nax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nax RCSB], [https://www.ebi.ac.uk/pdbsum/1nax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nax ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/THB_HUMAN THB_HUMAN] Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:[https://omim.org/entry/188570 188570]. GTHR is a disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).<ref>PMID:2510172</ref> <ref>PMID:2153155</ref> <ref>PMID:1846005</ref> <ref>PMID:1661299</ref> <ref>PMID:1653889</ref> <ref>PMID:1563081</ref> <ref>PMID:1314846</ref> <ref>PMID:1619012</ref> <ref>PMID:1587388</ref> <ref>PMID:1324420</ref> <ref>PMID:8514853</ref> <ref>PMID:8175986</ref> <ref>PMID:7833659</ref> <ref>PMID:8664910</ref> <ref>PMID:8889584</ref> <ref>PMID:10660344</ref> <ref>PMID:16804041</ref> <ref>PMID:19268523</ref> Defects in THRB are the cause of generalized thyroid hormone resistance autosomal recessive (GTHRAR) [MIM:[https://omim.org/entry/274300 274300]. An autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone. Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:[https://omim.org/entry/145650 145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.<ref>PMID:7528740</ref> <ref>PMID:8381821</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/THB_HUMAN THB_HUMAN] High affinity receptor for triiodothyronine.<ref>PMID:17418816</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/1nax_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nax ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/THB_HUMAN THB_HUMAN]] High affinity receptor for triiodothyronine.<ref>PMID:17418816</ref>
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*[[Thyroid hormone receptor 3D structures|Thyroid hormone receptor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1nax]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAX OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012699376</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bladh, L G.]]
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[[Category: Large Structures]]
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[[Category: Collazo, A M.Garcia.]]
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[[Category: Bladh LG]]
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[[Category: Garg, N.]]
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[[Category: Garcia Collazo AM]]
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[[Category: George, R.]]
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[[Category: Garg N]]
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[[Category: Grover, G.]]
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[[Category: George R]]
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[[Category: Husman, B.]]
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[[Category: Grover G]]
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[[Category: Koehler, K.]]
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[[Category: Husman B]]
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[[Category: Li, Y L.]]
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[[Category: Koehler K]]
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[[Category: Litten, C.]]
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[[Category: Li YL]]
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[[Category: Ljunggren, J.]]
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[[Category: Litten C]]
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[[Category: Malm, J.]]
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[[Category: Ljunggren J]]
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[[Category: Mellin, C.]]
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[[Category: Malm J]]
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[[Category: Mellstrom, K.]]
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[[Category: Mellin C]]
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[[Category: Persson, K.]]
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[[Category: Mellstrom K]]
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[[Category: Sleph, P G.]]
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[[Category: Persson K]]
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[[Category: Ye, L.]]
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[[Category: Sleph PG]]
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[[Category: Complex]]
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[[Category: Ye L]]
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[[Category: Membrane protein]]
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[[Category: Nuclear receptor]]
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[[Category: Thyroid receptor]]
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Current revision

Thyroid receptor beta1 in complex with a beta-selective ligand

PDB ID 1nax

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