3ik5

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{{STRUCTURE_3ik5| PDB=3ik5 | SCENE= }}
 
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===SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)===
 
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{{ABSTRACT_PUBMED_20124696}}
 
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==Disease==
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==SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)==
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[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[http://omim.org/entry/610163 610163]]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref>
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<StructureSection load='3ik5' size='340' side='right'caption='[[3ik5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ik5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_cpz Simian immunodeficiency virus - cpz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik5 OCA], [https://pdbe.org/3ik5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEF_SIVMA NEF_SIVMA] Seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Probably involved in viral immune evasion mechanisms (By similarity). In infected CD4(+) T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules. Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ik5 ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
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*[[CD3 3D structures|CD3 3D structures]]
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*[[Protein Nef 3D structures|Protein Nef 3D structures]]
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==About this Structure==
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__TOC__
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[[3ik5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA].
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</StructureSection>
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[[Category: Homo sapiens]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:020124696</ref><references group="xtra"/><references/>
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[[Category: Simian immunodeficiency virus - cpz]]
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[[Category: Simian immunodeficiency virus]]
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[[Category: Kim WM]]
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[[Category: Kim, W M.]]
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[[Category: Sigalov AB]]
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[[Category: Sigalov, A B.]]
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[[Category: Stern LJ]]
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[[Category: Stern, L J.]]
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[[Category: Cell membrane]]
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[[Category: Disulfide bond]]
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[[Category: Host-virus interaction]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Myristate]]
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[[Category: Phosphoprotein]]
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[[Category: Protein-protein complex]]
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[[Category: Receptor]]
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[[Category: Transmembrane]]
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[[Category: Viral immunoevasion]]
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[[Category: Viral protein-antiviral protein complex]]
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[[Category: Viral protein-signaling protein complex]]
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[[Category: Virulence]]
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Current revision

SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)

PDB ID 3ik5

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