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1xni
From Proteopedia
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| - | {{STRUCTURE_1xni| PDB=1xni | SCENE= }} | ||
| - | ===Tandem Tudor Domain of 53BP1=== | ||
| - | {{ABSTRACT_PUBMED_15525939}} | ||
| - | == | + | ==Tandem Tudor Domain of 53BP1== |
| - | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN | + | <StructureSection load='1xni' size='340' side='right'caption='[[1xni]], [[Resolution|resolution]] 2.80Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[1xni]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XNI FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xni OCA], [https://pdbe.org/1xni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xni RCSB], [https://www.ebi.ac.uk/pdbsum/1xni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xni ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | + | == Disease == | |
| - | + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |
| - | + | == Function == | |
| - | <references | + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: DiTullio | + | [[Category: Large Structures]] |
| - | [[Category: Gorgoulis | + | [[Category: DiTullio Jr RA]] |
| - | [[Category: Halazonetis | + | [[Category: Gorgoulis VG]] |
| - | [[Category: Huyen | + | [[Category: Halazonetis TD]] |
| - | [[Category: Mellert | + | [[Category: Huyen Y]] |
| - | [[Category: Petty | + | [[Category: Mellert HS]] |
| - | [[Category: Sheston | + | [[Category: Petty TJ]] |
| - | [[Category: Stavridi | + | [[Category: Sheston EA]] |
| - | [[Category: Zacharatos | + | [[Category: Stavridi ES]] |
| - | [[Category: Zgheib | + | [[Category: Zacharatos P]] |
| - | + | [[Category: Zgheib O]] | |
| - | + | ||
| - | + | ||
Current revision
Tandem Tudor Domain of 53BP1
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