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2cb1

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[[Image:2cb1.jpg|left|200px]]<br /><applet load="2cb1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cb1, resolution 2.00&Aring;" />
 
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'''CRYSTAL STRUCTURE OF O-ACTETYL HOMOSERINE SULFHYDRYLASE FROM THERMUS THERMOPHILUS HB8,OAH2.'''<br />
 
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==About this Structure==
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==Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2.==
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2CB1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Active as [http://en.wikipedia.org/wiki/O-acetylhomoserine_aminocarboxypropyltransferase O-acetylhomoserine aminocarboxypropyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.49 2.5.1.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CB1 OCA].
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<StructureSection load='2cb1' size='340' side='right'caption='[[2cb1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: O-acetylhomoserine aminocarboxypropyltransferase]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2cb1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CB1 FirstGlance]. <br>
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[[Category: Thermus thermophilus]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Agari, Y.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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[[Category: Ebihara, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cb1 OCA], [https://pdbe.org/2cb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cb1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cb1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cb1 TOPSAN]</span></td></tr>
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[[Category: Imagawa, T.]]
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</table>
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[[Category: Kanagawa, M.]]
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== Function ==
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[[Category: Kuramitsu, S.]]
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[https://www.uniprot.org/uniprot/METY2_THET8 METY2_THET8] Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine. Shows a very low CTT gamma-synthase activity.<ref>PMID:15215603</ref>
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[[Category: Kuroishi, C.]]
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== Evolutionary Conservation ==
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[[Category: Nakagawa, N.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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Check<jmol>
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[[Category: Tsuge, H.]]
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<jmolCheckbox>
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[[Category: Utsunomiya, H.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/2cb1_consurf.spt"</scriptWhenChecked>
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[[Category: Yokoyama, S.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: homoserine]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: lyase]]
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</jmolCheckbox>
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[[Category: plp enzyme]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cb1 ConSurf].
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[[Category: riken structural genomics/proteomics initiative]]
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<div style="clear:both"></div>
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[[Category: rsgi]]
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== References ==
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[[Category: structural genomics]]
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<references/>
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[[Category: sulfhydrylase]]
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__TOC__
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</StructureSection>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:46:47 2008''
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Agari Y]]
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[[Category: Ebihara A]]
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[[Category: Imagawa T]]
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[[Category: Kanagawa M]]
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[[Category: Kuramitsu S]]
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[[Category: Kuroishi C]]
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[[Category: Nakagawa N]]
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[[Category: Tsuge H]]
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[[Category: Utsunomiya H]]
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[[Category: Yokoyama S]]

Current revision

Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2.

PDB ID 2cb1

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OCA

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