4gow

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{{STRUCTURE_4gow| PDB=4gow | SCENE= }}
 
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===Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex===
 
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{{ABSTRACT_PUBMED_23178170}}
 
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==Disease==
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==Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex==
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[[http://www.uniprot.org/uniprot/KCNQ4_HUMAN KCNQ4_HUMAN]] Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A) [MIM:[http://omim.org/entry/600101 600101]]. DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:10025409</ref><ref>PMID:10369879</ref><ref>PMID:10571947</ref><ref>PMID:10925378</ref><ref>PMID:21242547</ref>
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<StructureSection load='4gow' size='340' side='right'caption='[[4gow]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4gow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GOW FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/KCNQ4_HUMAN KCNQ4_HUMAN]] Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.<ref>PMID:11245603</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gow OCA], [https://pdbe.org/4gow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gow RCSB], [https://www.ebi.ac.uk/pdbsum/4gow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gow ProSAT]</span></td></tr>
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[[4gow]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOW OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
==See Also==
==See Also==
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*[[Calmodulin|Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Galactosidase|Galactosidase]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<references group="xtra"/><references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chang, A.]]
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[[Category: Large Structures]]
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[[Category: Minor, D L.]]
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[[Category: Chang A]]
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[[Category: Tolia, A.]]
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[[Category: Minor Jr DL]]
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[[Category: Xu, Q.]]
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[[Category: Tolia A]]
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[[Category: Calmodulin]]
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[[Category: Xu Q]]
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[[Category: Ion channel]]
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[[Category: Potassium channel]]
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[[Category: Protein binding]]
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[[Category: Protein complex]]
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Current revision

Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex

PDB ID 4gow

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