1d3k

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{{STRUCTURE_1d3k| PDB=1d3k | SCENE= }}
 
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===HUMAN SERUM TRANSFERRIN===
 
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{{ABSTRACT_PUBMED_10739246}}
 
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==Disease==
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==HUMAN SERUM TRANSFERRIN==
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref><ref>PMID:15466165</ref>
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<StructureSection load='1d3k' size='340' side='right'caption='[[1d3k]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1d3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D3K FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d3k OCA], [https://pdbe.org/1d3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d3k RCSB], [https://www.ebi.ac.uk/pdbsum/1d3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d3k ProSAT]</span></td></tr>
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[[1d3k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3K OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/1d3k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d3k ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Transferrin|Transferrin]]
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010739246</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brayer, G D.]]
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[[Category: Large Structures]]
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[[Category: Chen, J.]]
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[[Category: Brayer GD]]
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[[Category: Luo, Y.]]
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[[Category: Chen J]]
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[[Category: MacGillivray, R T.A.]]
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[[Category: Luo Y]]
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[[Category: Mason, A.]]
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[[Category: MacGillivray RTA]]
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[[Category: Murphy, M E.P.]]
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[[Category: Mason A]]
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[[Category: Wang, Y.]]
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[[Category: Murphy MEP]]
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[[Category: Woodworth, R C.]]
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[[Category: Wang Y]]
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[[Category: Yang, H W.]]
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[[Category: Woodworth RC]]
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[[Category: Carbonate]]
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[[Category: Yang H-W]]
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[[Category: Glycoprotein]]
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[[Category: Iron transport]]
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[[Category: Iron-release]]
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[[Category: Metal transport]]
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[[Category: Nlobe]]
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[[Category: Transferrin]]
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Current revision

HUMAN SERUM TRANSFERRIN

PDB ID 1d3k

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