1xon

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{{STRUCTURE_1xon| PDB=1xon | SCENE= }}
 
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===Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast===
 
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{{ABSTRACT_PUBMED_15576036}}
 
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==Disease==
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==Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
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<StructureSection load='1xon' size='340' side='right'caption='[[1xon]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1xon]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XON FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref><ref>PMID:15576036</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIL:3-(CYCLOPENTYLOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-METHOXYBENZAMIDE'>PIL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xon OCA], [https://pdbe.org/1xon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xon RCSB], [https://www.ebi.ac.uk/pdbsum/1xon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xon ProSAT]</span></td></tr>
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[[1xon]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XON OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[https://omim.org/entry/614613 614613]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xo/1xon_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xon ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015576036</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Artis, D R.]]
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[[Category: Large Structures]]
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[[Category: Bollag, G.]]
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[[Category: Artis DR]]
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[[Category: Card, G L.]]
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[[Category: Bollag G]]
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[[Category: England, B P.]]
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[[Category: Card GL]]
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[[Category: Fong, D.]]
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[[Category: England BP]]
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[[Category: Gillette, S.]]
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[[Category: Fong D]]
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[[Category: Ibrahim, P N.]]
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[[Category: Gillette S]]
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[[Category: Kim, S H.]]
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[[Category: Ibrahim PN]]
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[[Category: Lee, B.]]
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[[Category: Kim S-H]]
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[[Category: Luu, C.]]
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[[Category: Lee B]]
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[[Category: Milburn, M V.]]
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[[Category: Luu C]]
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[[Category: Powell, B.]]
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[[Category: Milburn MV]]
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[[Category: Schlessinger, J.]]
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[[Category: Powell B]]
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[[Category: Suzuki, Y.]]
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[[Category: Schlessinger J]]
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[[Category: Tabrizizad, M.]]
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[[Category: Suzuki Y]]
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[[Category: Zhang, K Y.J.]]
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[[Category: Tabrizizad M]]
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[[Category: Hydrolase]]
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[[Category: Zhang KYJ]]
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[[Category: Pde]]
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[[Category: Pde4d]]
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[[Category: Phosphodiesterase]]
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[[Category: Piclamilast]]
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Current revision

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast

PDB ID 1xon

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