2cfy

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[[Image:2cfy.gif|left|200px]]<br /><applet load="2cfy" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cfy, resolution 2.70&Aring;" />
 
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'''CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1'''<br />
 
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==About this Structure==
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==Crystal structure of human thioredoxin reductase 1==
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2CFY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FAD:'>FAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] Known structural/functional Site: <scene name='pdbsite=AC1:Fad+Binding+Site+For+Chain+F'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFY OCA].
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<StructureSection load='2cfy' size='340' side='right'caption='[[2cfy]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2cfy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFY FirstGlance]. <br>
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[[Category: Thioredoxin-disulfide reductase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Arrowsmith, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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[[Category: Debreczeni, J E.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfy OCA], [https://pdbe.org/2cfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfy RCSB], [https://www.ebi.ac.uk/pdbsum/2cfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfy ProSAT]</span></td></tr>
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[[Category: Delft, F Von.]]
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</table>
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[[Category: Edwards, A.]]
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== Function ==
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[[Category: Johansson, C.]]
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[https://www.uniprot.org/uniprot/TRXR1_HUMAN TRXR1_HUMAN] Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.<ref>PMID:9774665</ref> <ref>PMID:8577704</ref> <ref>PMID:15199063</ref> <ref>PMID:18042542</ref>
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[[Category: Kavanagh, K.]]
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== Evolutionary Conservation ==
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[[Category: Oppermann, U.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Savitsky, P.]]
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Check<jmol>
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[[Category: Sundstrom, M.]]
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<jmolCheckbox>
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[[Category: Weigelt, J.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfy_consurf.spt"</scriptWhenChecked>
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[[Category: FAD]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: nadp]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: oxidoreductase]]
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</jmolCheckbox>
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[[Category: phosphorylation]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfy ConSurf].
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[[Category: redox-active center]]
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:48:12 2008''
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==See Also==
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*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Debreczeni JE]]
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[[Category: Edwards A]]
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[[Category: Johansson C]]
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[[Category: Kavanagh K]]
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[[Category: Oppermann U]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of human thioredoxin reductase 1

PDB ID 2cfy

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