3e17

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{{STRUCTURE_3e17| PDB=3e17 | SCENE= }}
 
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===Crystal structure of the second PDZ domain from human Zona Occludens-2===
 
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{{ABSTRACT_PUBMED_19342771}}
 
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==Disease==
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==Crystal structure of the second PDZ domain from human Zona Occludens-2==
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[[http://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[http://omim.org/entry/607748 607748]]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref>
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<StructureSection load='3e17' size='340' side='right'caption='[[3e17]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3e17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E17 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e17 OCA], [https://pdbe.org/3e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e17 RCSB], [https://www.ebi.ac.uk/pdbsum/3e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e17 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[https://omim.org/entry/607748 607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Plays a role in tight junctions and adherens junctions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e17_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e17 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human zonula occludens 2 (ZO-2) protein is a multi-domain protein that consists of an SH3 domain, a GK domain and three copies of a PDZ domain with slight divergence. The three PDZ domains act as protein-recognition modules that may mediate protein assembly and subunit localization. The crystal structure of the second PDZ domain of ZO-2 (ZO-2 PDZ2) was determined by molecular replacement at 1.75 A resolution, revealing a dimer in the asymmetric unit. The dimer is stabilized by extensive symmetrical domain-swapping of the beta1 and beta2 strands. Structural comparison shows that the ZO-2 PDZ2 homodimer may have a similar ligand-binding pattern to the ZO-1 PDZ2-connexin 43 complex.
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==Function==
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Structure of the second PDZ domain from human zonula occludens 2.,Chen H, Tong S, Li X, Wu J, Zhu Z, Niu L, Teng M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Apr 1;65(Pt, 4):327-30. Epub 2009 Mar 25. PMID:19342771<ref>PMID:19342771</ref>
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[[http://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Plays a role in tight junctions and adherens junctions.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3e17]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E17 OCA].
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</div>
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<div class="pdbe-citations 3e17" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:019342771</ref><references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, H.]]
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[[Category: Large Structures]]
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[[Category: Niu, L W.]]
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[[Category: Chen H]]
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[[Category: Teng, M K.]]
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[[Category: Niu LW]]
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[[Category: Tong, S L.]]
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[[Category: Teng MK]]
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[[Category: Alternative promoter usage]]
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[[Category: Tong SL]]
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[[Category: Cell adhesion]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Disease mutation]]
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[[Category: Domain swapping]]
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[[Category: Membrane]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sh3 domain]]
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[[Category: Tight junction]]
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Current revision

Crystal structure of the second PDZ domain from human Zona Occludens-2

PDB ID 3e17

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