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3qb1

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{{STRUCTURE_3qb1| PDB=3qb1 | SCENE= }}
 
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===Interleukin-2 mutant D10===
 
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{{ABSTRACT_PUBMED_22446627}}
 
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==Disease==
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==Interleukin-2 mutant D10==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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<StructureSection load='3qb1' size='340' side='right'caption='[[3qb1]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3qb1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QB1 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qb1 OCA], [https://pdbe.org/3qb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qb1 RCSB], [https://www.ebi.ac.uk/pdbsum/3qb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qb1 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3qb1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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== Function ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022446627</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bates, D L.]]
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[[Category: Large Structures]]
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[[Category: Bowman, G R.]]
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[[Category: Bates DL]]
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[[Category: Boyman, O.]]
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[[Category: Bowman GR]]
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[[Category: C G., Fathman.]]
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[[Category: Boyman O]]
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[[Category: Garcia, K C.]]
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[[Category: Fathman CG]]
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[[Category: Khort, H E.]]
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[[Category: Garcia KC]]
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[[Category: Krieg, C.]]
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[[Category: Khort HE]]
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[[Category: Levin, A M.]]
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[[Category: Krieg C]]
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[[Category: Lin, J T.]]
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[[Category: Levin AM]]
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[[Category: Novick, P.]]
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[[Category: Lin JT]]
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[[Category: Pande, V S.]]
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[[Category: Novick P]]
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[[Category: Ring, A M.]]
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[[Category: Pande VS]]
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[[Category: Su, L.]]
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[[Category: Ring AM]]
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[[Category: Cytokine]]
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[[Category: Su L]]
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[[Category: High affinity il-2 cytokine]]
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Current revision

Interleukin-2 mutant D10

PDB ID 3qb1

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