2fic

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{{STRUCTURE_2fic| PDB=2fic | SCENE= }}
 
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===The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition===
 
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{{ABSTRACT_PUBMED_17059209}}
 
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==Disease==
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==The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition==
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[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[http://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>
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<StructureSection load='2fic' size='340' side='right'caption='[[2fic]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2fic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FIC FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fic OCA], [https://pdbe.org/2fic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fic RCSB], [https://www.ebi.ac.uk/pdbsum/2fic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fic ProSAT]</span></td></tr>
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[[2fic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIC OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[https://omim.org/entry/255200 255200]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>
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<ref group="xtra">PMID:017059209</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/2fic_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fic ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Casal, E.]]
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[[Category: Large Structures]]
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[[Category: Duhadaway, J B.]]
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[[Category: Casal E]]
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[[Category: Federici, L.]]
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[[Category: Duhadaway JB]]
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[[Category: Fernandez-Recio, J.]]
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[[Category: Federici L]]
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[[Category: Laue, E D.]]
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[[Category: Fernandez-Recio J]]
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[[Category: Luisi, B F.]]
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[[Category: Laue ED]]
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[[Category: Miguel, R N.]]
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[[Category: Luisi BF]]
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[[Category: Prendergast, G C.]]
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[[Category: Miguel RN]]
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[[Category: Priego, E M.]]
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[[Category: Prendergast GC]]
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[[Category: Zhang, W.]]
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[[Category: Priego EM]]
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[[Category: Bar domain]]
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[[Category: Zhang W]]
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[[Category: Coiled-coil]]
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[[Category: Endocytosis-exocytosis]]
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[[Category: Endocytosis/exocytosis]]
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[[Category: Homodimer]]
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[[Category: Membrane protein complex]]
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Current revision

The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition

PDB ID 2fic

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