3tf3

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{{STRUCTURE_3tf3| PDB=3tf3 | SCENE= }}
 
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===Crystal structure of metal-free Human Arginase I===
 
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{{ABSTRACT_PUBMED_21870783}}
 
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==Disease==
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==Crystal structure of metal-free Human Arginase I==
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[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref><ref>PMID:7649538</ref>
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<StructureSection load='3tf3' size='340' side='right'caption='[[3tf3]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tf3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TF3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tf3 OCA], [https://pdbe.org/3tf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tf3 RCSB], [https://www.ebi.ac.uk/pdbsum/3tf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tf3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]
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==About this Structure==
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==See Also==
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[[3tf3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF3 OCA].
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*[[Arginase 3D structures|Arginase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021870783</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Arginase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Antonio, E L.D.]]
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[[Category: Large Structures]]
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[[Category: Christianson, D W.]]
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[[Category: Christianson DW]]
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[[Category: Arginase fold]]
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[[Category: D'Antonio EL]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of metal-free Human Arginase I

PDB ID 3tf3

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