1p8d

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{{STRUCTURE_1p8d| PDB=1p8d | SCENE= }}
 
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===X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol===
 
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{{ABSTRACT_PUBMED_12736258}}
 
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==Function==
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==X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol==
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[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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<StructureSection load='1p8d' size='340' side='right'caption='[[1p8d]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO1:17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL'>CO1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8d OCA], [https://pdbe.org/1p8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8d RCSB], [https://www.ebi.ac.uk/pdbsum/1p8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8d ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[1p8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8D OCA].
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*[[Liver X receptor|Liver X receptor]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012736258</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bledsoe, R K.]]
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[[Category: Large Structures]]
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[[Category: Boggs, S.]]
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[[Category: Bledsoe RK]]
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[[Category: Collins, J L.]]
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[[Category: Boggs S]]
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[[Category: Lambert, M H.]]
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[[Category: Collins JL]]
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[[Category: McKee, D D.]]
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[[Category: Lambert MH]]
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[[Category: Miller, A B.]]
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[[Category: McKee DD]]
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[[Category: Moore, J.]]
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[[Category: Miller AB]]
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[[Category: Moore, L.]]
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[[Category: Moore J]]
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[[Category: Nichols, J.]]
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[[Category: Moore L]]
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[[Category: Parks, D.]]
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[[Category: Nichols J]]
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[[Category: Watson, M.]]
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[[Category: Parks D]]
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[[Category: Williams, S.]]
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[[Category: Watson M]]
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[[Category: Willson, T M.]]
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[[Category: Williams S]]
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[[Category: Wisely, B.]]
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[[Category: Willson TM]]
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[[Category: Epoxycholesterol]]
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[[Category: Wisely B]]
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[[Category: Liver x receptor]]
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[[Category: Lxr]]
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[[Category: Membrane protein-protein binding complex]]
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[[Category: Nuclear receptor]]
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[[Category: Steroid receptor]]
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[[Category: Transcription]]
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Current revision

X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol

PDB ID 1p8d

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