3um3

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{{STRUCTURE_3um3| PDB=3um3 | SCENE= }}
 
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===Crystal structure of the Brox Bro1 domain in complex with the C-terminal tail of CHMP4B===
 
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{{ABSTRACT_PUBMED_22484091}}
 
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==Disease==
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==Crystal structure of the Brox Bro1 domain in complex with the C-terminal tail of CHMP4B==
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[[http://www.uniprot.org/uniprot/CHM4B_HUMAN CHM4B_HUMAN]] Defects in CHMP4B are the cause of cataract posterior polar type 3 (CTPP3) [MIM:[http://omim.org/entry/605387 605387]]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:17701905</ref>
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<StructureSection load='3um3' size='340' side='right'caption='[[3um3]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3um3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UM3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3um3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3um3 OCA], [https://pdbe.org/3um3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3um3 RCSB], [https://www.ebi.ac.uk/pdbsum/3um3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3um3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BROX_HUMAN BROX_HUMAN]
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/CHM4B_HUMAN CHM4B_HUMAN]] Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.<ref>PMID:12860994</ref><ref>PMID:14505569</ref><ref>PMID:14505570</ref><ref>PMID:14519844</ref><ref>PMID:18209100</ref>
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*[[Charged multivesicular body protein 3D structures|Charged multivesicular body protein 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3um3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM3 OCA].
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==Reference==
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<ref group="xtra">PMID:022484091</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jiang, J S.]]
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[[Category: Large Structures]]
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[[Category: Mu, R L.]]
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[[Category: Jiang JS]]
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[[Category: Xiao, T.]]
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[[Category: Mu RL]]
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[[Category: Alpha-helix of c-terminal tail of chmp4b]]
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[[Category: Xiao T]]
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[[Category: Brox]]
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[[Category: Chmp]]
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[[Category: Escrt-iii]]
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[[Category: Membrane protein-transport protein complex]]
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Current revision

Crystal structure of the Brox Bro1 domain in complex with the C-terminal tail of CHMP4B

PDB ID 3um3

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