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2cke

From Proteopedia

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[[Image:2cke.jpg|left|200px]]<br /><applet load="2cke" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cke, resolution 2.80&Aring;" />
 
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'''HUMAN DEATH-ASSOCIATED DRP-1 KINASE IN COMPLEX WITH INHIBITOR'''<br />
 
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==About this Structure==
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==Human death-associated DRP-1 kinase in complex with inhibitor==
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2CKE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=IQU:'>IQU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Known structural/functional Site: <scene name='pdbsite=AC1:Iqu+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKE OCA].
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<StructureSection load='2cke' size='340' side='right'caption='[[2cke]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Non-specific serine/threonine protein kinase]]
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<table><tr><td colspan='2'>[[2cke]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKE FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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[[Category: Kursula, P.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQU:N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE'>IQU</scene></td></tr>
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[[Category: Wilmanns, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cke OCA], [https://pdbe.org/2cke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cke RCSB], [https://www.ebi.ac.uk/pdbsum/2cke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cke ProSAT]</span></td></tr>
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[[Category: IQU]]
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</table>
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[[Category: apoptosis]]
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== Function ==
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[[Category: atp-binding]]
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[https://www.uniprot.org/uniprot/DAPK2_HUMAN DAPK2_HUMAN] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.<ref>PMID:10376525</ref> <ref>PMID:10629061</ref> <ref>PMID:21408167</ref> <ref>PMID:11230133</ref> <ref>PMID:11980920</ref> <ref>PMID:17347302</ref> <ref>PMID:18957423</ref> Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.<ref>PMID:10376525</ref> <ref>PMID:10629061</ref> <ref>PMID:21408167</ref> <ref>PMID:11230133</ref> <ref>PMID:11980920</ref> <ref>PMID:17347302</ref> <ref>PMID:18957423</ref>
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[[Category: calmodulin-binding]]
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== Evolutionary Conservation ==
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[[Category: inhibitor]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: kinase]]
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Check<jmol>
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[[Category: nucleotide-binding]]
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<jmolCheckbox>
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[[Category: phosphorylation]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2cke_consurf.spt"</scriptWhenChecked>
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[[Category: protein kinase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: serine/threonine-protein kinase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: transferase]]
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</jmolCheckbox>
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[[Category: transferase/inhibitor complex]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cke ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:49:34 2008''
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==See Also==
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
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*[[Death-associated protein kinase 3D structures|Death-associated protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kursula P]]
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[[Category: Wilmanns M]]

Current revision

Human death-associated DRP-1 kinase in complex with inhibitor

PDB ID 2cke

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