1r2b

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{{STRUCTURE_1r2b| PDB=1r2b | SCENE= }}
 
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===Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide===
 
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{{ABSTRACT_PUBMED_14690607}}
 
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==Disease==
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==Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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<StructureSection load='1r2b' size='340' side='right'caption='[[1r2b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r2b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2b OCA], [https://pdbe.org/1r2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2b RCSB], [https://www.ebi.ac.uk/pdbsum/1r2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2b ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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== Function ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r2b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r2b ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref><ref>PMID:18280243</ref> [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
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==About this Structure==
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== References ==
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[[1r2b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2B OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:014690607</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ahmad, K F.]]
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[[Category: Large Structures]]
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[[Category: Bouchard, D.]]
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[[Category: Ahmad KF]]
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[[Category: Kiang, C L.]]
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[[Category: Bouchard D]]
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[[Category: Lax, S A.]]
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[[Category: Kiang CL]]
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[[Category: Licht, J D.]]
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[[Category: Lax SA]]
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[[Category: Liu, J.]]
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[[Category: Licht JD]]
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[[Category: Mayer, S.]]
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[[Category: Liu J]]
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[[Category: Melnick, A.]]
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[[Category: Mayer S]]
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[[Category: Prive, G G.]]
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[[Category: Melnick A]]
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[[Category: B-cell lymphoma]]
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[[Category: Prive GG]]
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[[Category: Btb domain]]
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[[Category: Hdac complex]]
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[[Category: Transcription]]
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[[Category: Transcriptional repression]]
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Current revision

Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide

PDB ID 1r2b

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