2jxc

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{{STRUCTURE_2jxc| PDB=2jxc | SCENE= }}
 
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===Structure of the EPS15-EH2 Stonin2 Complex===
 
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{{ABSTRACT_PUBMED_018200045}}
 
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==Disease==
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==Structure of the EPS15-EH2 Stonin2 Complex==
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[[http://www.uniprot.org/uniprot/EP15_HUMAN EP15_HUMAN]] Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.
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<StructureSection load='2jxc' size='340' side='right'caption='[[2jxc]]' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2jxc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXC FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/EP15_HUMAN EP15_HUMAN]] Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.<ref>PMID:18362181</ref><ref>PMID:19458185</ref><ref>PMID:22648170</ref><ref>PMID:16903783</ref> [[http://www.uniprot.org/uniprot/STON2_HUMAN STON2_HUMAN]] Adapter protein involved in endocytic machinery. May be involved in the vesicle recycling. May facilitate clathrin-coated vesicle uncoating.<ref>PMID:11454741</ref><ref>PMID:11381094</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxc OCA], [https://pdbe.org/2jxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxc RCSB], [https://www.ebi.ac.uk/pdbsum/2jxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxc ProSAT]</span></td></tr>
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[[2jxc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXC OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN] Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.
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<references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN] Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.<ref>PMID:18362181</ref> <ref>PMID:19458185</ref> <ref>PMID:22648170</ref> <ref>PMID:16903783</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxc ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Groemping, Y.]]
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[[Category: Large Structures]]
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[[Category: Haucke, V.]]
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[[Category: Groemping Y]]
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[[Category: Jung, N.]]
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[[Category: Haucke V]]
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[[Category: Maritzen, T.]]
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[[Category: Jung N]]
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[[Category: Rumpf, J.]]
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[[Category: Maritzen T]]
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[[Category: Sattler, M.]]
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[[Category: Rumpf J]]
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[[Category: Simon, B.]]
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[[Category: Sattler M]]
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[[Category: Endocytosis]]
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[[Category: Simon B]]
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[[Category: Endocytosis-protein binding complex]]
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[[Category: Membrane]]
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[[Category: Phosphorylation]]
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[[Category: Proto-oncogene]]
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[[Category: Sh3-binding]]
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Current revision

Structure of the EPS15-EH2 Stonin2 Complex

PDB ID 2jxc

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