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3dwb

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{{STRUCTURE_3dwb| PDB=3dwb | SCENE= }}
 
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===structure of human ECE-1 complexed with phosphoramidon===
 
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{{ABSTRACT_PUBMED_18992253}}
 
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==Disease==
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==structure of human ECE-1 complexed with phosphoramidon==
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[[http://www.uniprot.org/uniprot/ECE1_HUMAN ECE1_HUMAN]] Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD) [MIM:[http://omim.org/entry/613870 613870]]. It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.<ref>PMID:9915973</ref>
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<StructureSection load='3dwb' size='340' side='right'caption='[[3dwb]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3dwb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DWB FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ECE1_HUMAN ECE1_HUMAN]] Converts big endothelin-1 to endothelin-1.<ref>PMID:9396733</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5HD:5-(2-HYDROXYETHYL)NONANE-1,9-DIOL'>5HD</scene>, <scene name='pdbligand=RDF:N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN'>RDF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwb OCA], [https://pdbe.org/3dwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dwb RCSB], [https://www.ebi.ac.uk/pdbsum/3dwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwb ProSAT]</span></td></tr>
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[[3dwb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWB OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/ECE1_HUMAN ECE1_HUMAN] Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD) [MIM:[https://omim.org/entry/613870 613870]. It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.<ref>PMID:9915973</ref>
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<ref group="xtra">PMID:018992253</ref><references group="xtra"/><references/>
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== Function ==
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[[Category: Endothelin-converting enzyme 1]]
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[https://www.uniprot.org/uniprot/ECE1_HUMAN ECE1_HUMAN] Converts big endothelin-1 to endothelin-1.<ref>PMID:9396733</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dwb ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Oefner, C.]]
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[[Category: Large Structures]]
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[[Category: Disease mutation]]
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[[Category: Oefner C]]
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[[Category: Glycoprotein]]
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[[Category: Hirschsprung disease]]
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[[Category: Hydrolase]]
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[[Category: Mch_ece_h_25a1_lt1 pdb]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Phosphoprotein]]
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[[Category: Protease]]
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[[Category: Protein]]
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[[Category: Signal-anchor]]
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[[Category: Transmembrane]]
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Current revision

structure of human ECE-1 complexed with phosphoramidon

PDB ID 3dwb

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